10% Off
Ursocol300 mg
Sun Pharmaceutical Ltd.
৳225.00
Add to cart
Udiliva300 mg
Tablet
By
Best PriceTk /
1
Alternatives
Price
Medicine overview
Indications of Udiliva 300 mg
Udiliva 300 mg is indicated for the treatment of Cholestasis (Jaundice)Viral HepatitisAlcoholic Fatty LiverPrimary Billiary Cirrhosis (PBC)Primary Sclerosing Cholangitis (PSC)Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).
Theropeutic Class
Anti-gallstones drugs: Bile Acids
Pharmacology
Udiliva 300 mg is a naturally occurring bile acid used to treat different hepatobilliary disorders.
Absorption
Udiliva 300 mg also promotes the formation of liquid cholesterol crystal complexes which enhance removal of the cholesterol from the gallbladder into the intestine to be expelled. Udiliva 300 mg improves cholestatic liver diseases by- Protecting cholangiocytes against cytotoxicity of hydrophobic bile acids Stimulating hepatobilliary secretion Protecting hepatocytes against bile acid-induced apoptosis Udiliva 300 mg is completely absorbed in the upper intestine.
Distribution
Therefore, alters bile composition from supersaturated to unsaturated.
Metabolism
Udiliva 300 mg achieves this through a few mechanisms: it reduces cholesterol absorption, suppresses liver cholesterol synthesis and it does not inhibit bile acid synthesis. Udiliva 300 mg improves cholestatic liver diseases by- Protecting cholangiocytes against cytotoxicity of hydrophobic bile acids Stimulating hepatobilliary secretion Protecting hepatocytes against bile acid-induced apoptosis Udiliva 300 mg is completely absorbed in the upper intestine. After absorption Udiliva 300 mg enters the portal vein and undergoes extraction from portal blood by liver where it is conjugated with amino acid & that may be either glycine or taurine and then secreted into the hepatic bile ducts. The biologic half life of Udiliva 300 mg ranges from 3.5-5.8 days.
Excretion
After absorption Udiliva 300 mg enters the portal vein and undergoes extraction from portal blood by liver where it is conjugated with amino acid & that may be either glycine or taurine and then secreted into the hepatic bile ducts. Small quantities of Udiliva 300 mg appear in the circulation and very small amounts are excreted into urine.
Dosage & Administration of Udiliva 300 mg
Dissolution of Gall stones
Dosage:8-12 mg/kg/day either as single night time dose or in divided dosesPBC: 10-15 mg/kg/day in 2-4 divided dosesAcute Viral Hepatitis: 600 mg/dayAlcoholic Fatty Liver: 300 mg/dayPSC: 25-30 mg/kg/dayNASH: 13-15 mg/kg/day
| Condition | Dosage | Notes |
|---|---|---|
| Dissolution of Gall stones | 8-12 mg/kg/day either as single night time dose or in divided dosesPBC: 10-15 mg/kg/day in 2-4 divided dosesAcute Viral Hepatitis: 600 mg/dayAlcoholic Fatty Liver: 300 mg/dayPSC: 25-30 mg/kg/dayNASH: 13-15 mg/kg/day |
Interaction of Udiliva 300 mg
Udiliva 300 mg should not be used with drugs, such as oestrogenic hormones, that increase bile cholesterol. Concomitant administration with bile-acid binding drugs including antacids, charcoal and cholestyramine should be avoided, since this may reduce the effectiveness of therapy with Ursodeoxycholic acid.
Contraindications
Non-functioning gall-bladder calcified and pigmented gallstones, inflammatory bowel disease.
Side Effects of Udiliva 300 mg
Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.
Pregnancy & Lactation
Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.
Precautions & Warnings
It should be used cautiously in those with liver disease.
Storage Conditions
Store below 25° C. Protected from light and moisture. Keep the medicine out of the reach of children.
Frequently Asked Questions
What is Udiliva 300 mg used for?
Ursodeoxycholic Acid is indicated for the treatment of Cholestasis (Jaundice), Viral Hepatitis, Alcoholic Fatty Liver, Primary Billiary Cirrhosis (PBC), Primary Sclerosing Cholangitis (PSC), Dissolution of Gallstones and Non-Alcoholic Steato Hepatitis (NASH).
What is the dosage of Udiliva 300 mg?
Dissolution of Gall stones: 8-12 mg/kg/day either as single night time dose or in divided dosesPBC: 10-15 mg/kg/day in 2-4 divided dosesAcute Viral Hepatitis: 600 mg/dayAlcoholic Fatty Liver: 300 mg/dayPSC: 25-30 mg/kg/dayNASH: 13-15 mg/kg/day
What are the side effects of Udiliva 300 mg?
Commonly reported side effects are nausea, vomiting, diarrhoea, gallstone opacilication, pruritus.
Who should not take Udiliva 300 mg?
Non-functioning gall-bladder calcified and pigmented gallstones, inflammatory bowel disease.
What precautions should be taken with Udiliva 300 mg?
It should be used cautiously in those with liver disease.
Is Udiliva 300 mg safe during pregnancy and breastfeeding?
Pregnancy category B. No evidence of harm has been reported in pregnancy. It has been effectively used for the treatment of cholestasis of pregnancy during the last trimester without any side effects. Problems have not been documented in humans regarding breast feeding.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.