Natrilix SR 1.5 mg is indicated in the treatment of essential hypertension . It is effective in treating hypertension in patients with renal function impairment, although its diuretic effect is reduced. Natrilix SR 1.5 mg is also indicated for the treatment of salt and fluid retention associated with congestive heart failure.

Theropeutic Class

Thiazide diuretics & related drugs

Pharmacology

Natrilix SR 1.5 mg is a diuretic antihypertensive. It appears to cause vasodilation, probably by inhibiting the passage of calcium and other ions (sodium, potassium) across membranes. It has an extra-renal antihypertensive action resulting in a decrease in vascular hyperreactivity and a reduction in total peripheral and arteriolar resistance.

Dosage & Administration of Natrilix SR 1.5 mg

One tablet daily preferably in the morning. In more sever case Natrilix SR 1.5 mg can be combine with other categories of anti-hypertensive agent. The safety and effectiveness in pediatric patients have not been established

Dosage of Natrilix SR 1.5 mg

Interaction of Natrilix SR 1.5 mg

Other antihypertensive: Natrilix SR 1.5 mg may add to or potentiate the action of other antihypertensive drugs. Norepinephrine: Natrilix SR 1.5 mg like thiazides, may decrease arterial responsiveness to norepinephrine. Lithium: In general, diuretics should not be given concomitantly with lithium because they reduce its renal clearance and add a high risk of lithium toxicity.

Contraindications

This drug must not be taken in the following conditions: Hypersensitivity to sulfonamides Severe renal failure Hepatic encephalopathy or severe hepatic failure Hypokalaemia

Side Effects of Natrilix SR 1.5 mg

Side effects of Natrilix SR 1.5 mg include headache, anorexia, gastric irritation,nausea, vomiting, constipation, diarrhoea etc.

Pregnancy & Lactation

There are no adequate and well-controlled studies in pregnant women and so Natrilix SR 1.5 mg is not recommended. Mothers taking Natrilix SR 1.5 mg should not breast feed.

Precautions & Warnings

Monitoring of potassium and uric acid serum levels is recommended, especially in subjects with a predisposition or sensitivity to hypokalemia and in patients with gout. Although no allergic manifestations have been reported during clinical trials, patients with a history of allergy to sulfonamide derivatives should be closely monitored.

Overdose Effects of Natrilix SR 1.5 mg

Symptoms: These could include: allergies, skin rashes, epigastric pain, nausea, photosensitivity, dizziness, weakness and paraesthesia.Treatment: Treatment is supportive and symptomatic, directed at correcting the electrolyte abnormalities.

Storage Conditions

Store in a cool and dry place. Protect from light and moisture.

Drug Classes

Thiazide diuretics & related drugs

Mode Of Action

Pregnancy

There are no adequate and well-controlled studies in pregnant women and so Natrilix SR 1.5 mg is not recommended. Mothers taking Natrilix SR 1.5 mg should not breast feed.

Disclaimer

The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.