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Alben DS400 mg
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Vermikil400 mg
Chewable Tablet
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Medicine overview
Indications of Vermikil 400 mg
Vermikil 400 mg is indicated in single and mixed infestations of- Hookworm (AncylostomaNecator) Roundworm (Ascaris) Threadworm (Enterobius) Whipworm (Trichuris) Strongyloides Tapeworm Opisthorchi Hydatid.
Theropeutic Class
Anthelmintic
Pharmacology
Vermikil 400 mg is a broad spectrum benzimidazole anthelminthic drug.
Absorption
In addition to its vermicidal properties, it has both ovicidal and larvicidal activities.
Dosage & Administration of Vermikil 400 mg
Adults & children over 2 years
Dosage:400 mg (1 tablet or 10 ml suspension) as a single dose in cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale and Necator americanus
Notes:In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. If the patient is not cured on follow-up after three weeks, a second course of treatment is indicated
Children of 1-2 years
Dosage:Recommended dose is a single dose of 200 mg (5 ml suspension)
Children under 1 year
Dosage:Not recommended
In Hydatid disease (Echinococcosis)
Dosage:Vermikil 400 mg is given by mouth with meals in a dose of 400 mg twice daily for 28 days for patients weighing over 60 kg
Notes:A dose of 15 mg/kg body weight daily in two divided doses (to a maximum total daily dose of 800 mg) is used for patients weighing less than 60 kg. For cystic echinococcosis, the 28 days course may be repeated after 14 days without treatment, to a total of 3 treatment cycles. For alveolar echinococcosis, cycles of 28 days of treatment followed by 14 days without treatment, may need to continue for months or years. In giardiasis, 400 mg (1 tablet or 10 ml suspension) once daily for five days is used
| Condition | Dosage | Notes |
|---|---|---|
| Adults & children over 2 years | 400 mg (1 tablet or 10 ml suspension) as a single dose in cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale and Necator americanus | In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. If the patient is not cured on follow-up after three weeks, a second course of treatment is indicated |
| Children of 1-2 years | Recommended dose is a single dose of 200 mg (5 ml suspension) | |
| Children under 1 year | Not recommended | |
| In Hydatid disease (Echinococcosis) | Vermikil 400 mg is given by mouth with meals in a dose of 400 mg twice daily for 28 days for patients weighing over 60 kg | A dose of 15 mg/kg body weight daily in two divided doses (to a maximum total daily dose of 800 mg) is used for patients weighing less than 60 kg. For cystic echinococcosis, the 28 days course may be repeated after 14 days without treatment, to a total of 3 treatment cycles. For alveolar echinococcosis, cycles of 28 days of treatment followed by 14 days without treatment, may need to continue for months or years. In giardiasis, 400 mg (1 tablet or 10 ml suspension) once daily for five days is used |
Dosage of Vermikil 400 mg
Adults & children over 2 years
Dosage:400 mg (1 tablet or 10 ml suspension) as a single dose in cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale and Necator americanus
Notes:In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. If the patient is not cured on follow-up after three weeks, a second course of treatment is indicated
Children of 1-2 years
Dosage:Recommended dose is a single dose of 200 mg (5 ml suspension)
Children under 1 year
Dosage:Not recommended
In Hydatid disease (Echinococcosis)
Dosage:Vermikil 400 mg is given by mouth with meals in a dose of 400 mg twice daily for 28 days for patients weighing over 60 kg
Notes:A dose of 15 mg/kg body weight daily in two divided doses (to a maximum total daily dose of 800 mg) is used for patients weighing less than 60 kg. For cystic echinococcosis, the 28 days course may be repeated after 14 days without treatment, to a total of 3 treatment cycles. For alveolar echinococcosis, cycles of 28 days of treatment followed by 14 days without treatment, may need to continue for months or years. In giardiasis, 400 mg (1 tablet or 10 ml suspension) once daily for five days is used
| Condition | Dosage | Notes |
|---|---|---|
| Adults & children over 2 years | 400 mg (1 tablet or 10 ml suspension) as a single dose in cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale and Necator americanus | In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. If the patient is not cured on follow-up after three weeks, a second course of treatment is indicated |
| Children of 1-2 years | Recommended dose is a single dose of 200 mg (5 ml suspension) | |
| Children under 1 year | Not recommended | |
| In Hydatid disease (Echinococcosis) | Vermikil 400 mg is given by mouth with meals in a dose of 400 mg twice daily for 28 days for patients weighing over 60 kg | A dose of 15 mg/kg body weight daily in two divided doses (to a maximum total daily dose of 800 mg) is used for patients weighing less than 60 kg. For cystic echinococcosis, the 28 days course may be repeated after 14 days without treatment, to a total of 3 treatment cycles. For alveolar echinococcosis, cycles of 28 days of treatment followed by 14 days without treatment, may need to continue for months or years. In giardiasis, 400 mg (1 tablet or 10 ml suspension) once daily for five days is used |
Interaction of Vermikil 400 mg
No interaction involving Vermikil 400 mg, either pharmacodynamic or pharmacokinetic, has been reported.
Contraindications
Neonates: Vermikil 400 mg is not normally used in neonates.Children: Reduction of the dose from 400 mg to 200 mg may be indicated in children weighing less than 10 kg but there are no grounds for a general reduction in dosage to children.Pregnant woman: Vermikil 400 mg should not be given during pregnancy or women thought to be pregnant. No information is available on placental transfer.Concurrent disease: There is no evidence to suggest that dose should be altered in renal, hepatic or cardiac failure.
Side Effects of Vermikil 400 mg
Gastrointestinal disturbances, headache, dizziness, changes in liver enzymes, rarely reversible alopecia; rash, fever, blood disorders including leucopenia and pancytopenia reported; allergic shock if cyst leakage; convulsion and meningism in cerebral disease.
Pregnancy & Lactation
US FDA Pregnancy category of Vermikil 400 mg is C. So, Vermikil 400 mg should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Precautions & Warnings
Blood counts and liver function tests before treatment and twice during each cycle; breastfeeding; exclude pregnancy before starting treatment. Vermikil 400 mg should only be used in the treatment of Echinococcosis if there is constant medical supervision with regular monitoring of serum-transaminase concentrations and of leucocyte and platelet counts
Storage Conditions
Keep in a dry place, away from light and heat. Keep out of the reach of children.
Drug Classes
Anthelmintic
Mode Of Action
Vermikil 400 mg is a broad spectrum anthelmintic. Vermikil 400 mg exhibits vermicidal, ovicidal and larvicidal activities. The drug is thought to exert its anthelmintic effect by blocking glucose uptake in the susceptible helminths, thereby depleting the energy level until it becomes inadequate for survival. Immobilization is followed by the parasite. These events may be a consequence of the binding and subsequent inhibition of parasite tubulin polymerization by Vermikil 400 mg and its metabolites, although the drug also binds to human tubulin. Vermikil 400 mg is extensively metabolized, probably in the liver. Vermikil 400 mg is poorly absorbed from the gastrointestinal tract but rapidly undergoes extensive first-pass metabolism. The principal metabolite Vermikil 400 mg sulphoxide has anthelmintic activity and a plasma half-life of about 8.5 hrs. It is excreted in the urine together with other metabolites.
Pregnancy
US FDA Pregnancy category of Vermikil 400 mg is C. So, Vermikil 400 mg should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Frequently Asked Questions
What is Vermikil 400 mg used for?
Albendazole is indicated in single and mixed infestations of- Hookworm (Ancylostoma, Necator) Roundworm (Ascaris) Threadworm (Enterobius) Whipworm (Trichuris) Strongyloides Tapeworm Opisthorchi Hydatid.
What is the dosage of Vermikil 400 mg?
Adults & children over 2 years: 400 mg (1 tablet or 10 ml suspension) as a single dose in cases of Enterobius vermicularis, Trichuris trichiura, Ascaris lumbricoides, Ancylostoma duodenale and Necator americanus. In cases of strongyloidiasis or taeniasis, 400 mg (1 tablet or 10 ml suspension) daily should be given for 3 consecutive days. If the patient is not cured on follow-up after three weeks, …
What are the side effects of Vermikil 400 mg?
Gastrointestinal disturbances, headache, dizziness, changes in liver enzymes, rarely reversible alopecia; rash, fever, blood disorders including leucopenia and pancytopenia reported; allergic shock if cyst leakage; convulsion and meningism in cerebral disease.
Who should not take Vermikil 400 mg?
Neonates: Albendazole is not normally used in neonates.Children: Reduction of the dose from 400 mg to 200 mg may be indicated in children weighing less than 10 kg but there are no grounds for a general reduction in dosage to children.Pregnant woman: Albendazole should not be given during pregnancy or women thought to be pregnant. No information is available on placental transfer.Concurrent disease…
What precautions should be taken with Vermikil 400 mg?
Blood counts and liver function tests before treatment and twice during each cycle; breastfeeding; exclude pregnancy before starting treatment. Albendazole should only be used in the treatment of Echinococcosis if there is constant medical supervision with regular monitoring of serum-transaminase concentrations and of leucocyte and platelet counts
Is Vermikil 400 mg safe during pregnancy and breastfeeding?
US FDA Pregnancy category of Albendazole is C. So, Albendazole should be avoided in pregnancy and lactation unless the potential benefits to the other outweigh the possible risks to the fetus.
Disclaimer
The information provided is accurate to our best practices, but it does not replace professional medical advice. We cannot guarantee its completeness or accuracy. The absence of specific information about a drug should not be seen as an endorsement. We are not responsible for any consequences resulting from this information, so consult a healthcare professional for any concerns or questions.